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Dr. Miriam Lohr

Statistische Methoden in der Genetik und Chemometrie

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Miriam Lohr


Studies

  • Diplom (Statistics), TU Dortmund, 2010
    Thesis: Netzwerkanalysen von Brustkrebsdaten

 

Project assistance

  • DFG-Projekt RA 870/4-1: „Klinische Prognosen auf Grundlage von genregulatorischen Netzwerken“

 

Fields of Work

  • Extracting regulatory networks
  • Meta-analysis
  • Analysis of high-dimensional data
  • Survivalanalysis

 

Scientific Activities

 

Publications

  • Lohr M., Edlund K., Botling J., Hammad S., Hellwig B., Othman A., Berglund A., Lambe M., Holmberg L., Ekman S., Bergqvist M., Pontén F., Cadenas C., Marchan R., Hengstler J.G., Rahnenführer J., and Micke M. (2013): The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
    Cancer Letters 333(2):222-228.
  • Botling J., Edlund K., Lohr M., Hellwig B., Holmberg L., Lambe M., Berglund A., Ekman S., Bergqvist M., Pontén F., König A., Fernandez O., Karlsson M., Helenius G., Karlsson Ch., Rahnenführer J.,  Hengstler J.G., and Micke P. (2012): Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis and tissue microarray validation. Clinical Cancer Research [Epub ahead of print].
  • Godoy P., Cadenas C., Hellwig B., Marchan R., Stewart J., Reif R., Lohr M., Gehrmann M., Rahnenführer J., Schmidt M., and Hengstler J.G. (2012): Interferon-inducible guanylate binding protein GBP2 is associated with better prognosis in breast cancer and indicates an efficient T cell response. Breast Cancer [Epub ahead of print].
  • Schmidt M., Hellwig B., Hammad S., Othman A., Lohr M., Chen Z., Boehm D.,  Gebhard S., Petry I., Lebrecht A., Cadenas C., Marchan R., Stewart J.D., Solbach Ch., Holmberg L., Edlund K., Göransson Kultima H., Rody A., Berglund A.,  Lambe M., Isaksson A., Botling J., Karn Th., Müller V., Gerhold-Ay A., Cotarelo Ch., Sebastian M., Kronenwett R., Bojar H., Lehr H.-A., Sahin U., Koelbl H., Gehrmann M.,Micke P., Rahnenführer J., and Hengstler J.G. (2012): A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors. Clinical Cancer Research 18(9):2695-2703.
  • Lohr M., Köllmann C., Freis E., Hellwig B., Hengstler  J.G., Ickstadt K., and Rahnenführer J. (2012): Optimal Strategies for Sequential Validation of Significant Features from High-Dimensional Genomic Data. Journal of Toxicology and Environmental Health, Part A: Current Issues, 75(8-10): 447-460.
  • Lohr M., Godoy P., Hengstler J.G., Rahnenführer J. and Grzegorczyk M. (2010): Extracting differential regulatory sub-networks from genome-wide microarray expression data. Proceedings of the Seventh International Workshop on Computational Systems Biology (WCSB 2010), 63-66 [proceedings available here].
  •  Wuest S.E., Vijverberg K., Schmidt A., Weiss M., Gheyselinck J., Lohr M., Wellmer F., Rahnenführer J., von Mering C. and Grossniklaus U. (2010): Arabidopsis female gametophyte gene expression map reveals similarities between plant and animal gametes. Current Biology 20(6):506-512.